20 August 2018

Maple leaf extract could nip skin wrinkles in the bud

Maple trees are best known for their maple syrup and lovely fall foliage. But it turns out that the beauty of those leaves could be skin-deep — and that's a good ...

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Society welcome to this news briefing room ACS is 256th national national meeting and exposition in Boston we're joined today by dr. Hong MA from the University of Rhode Island's he's studying how a maple leaf extract could nip skin wrinkles in the bud dr. MA [Music] all right so I'm a researcher at the University of Rhode Island so we have been study may post pictures for almost ten years one decade so during the the courses of study maple different maple species we discovered a series of unique compounds they are plant based and accidents that occurred DSG's close work or containing cavity knees so those are the unique compounds find in red maple leaves extract so we further developed this red maple leaf extract to commercialize the product scada maple leaf a' and we also study the chemistry of maple IVA and evaluates the bio activities of maple IVA in its chemical compound and in today's case we are especially interested in if maple IVA and its major compounds could be used for skincare help asking health care and use to develop products for skin here so that's

the study we have here the target we studied for this case was cut elastase so it's an enzyme that is responsible for dye great degradation of elastin which is protein that supports the structure of skin so we won't say if maple IVA that red maple leaf extract and its major compounds could actually inhibit the activity of this enzyme to further prevention of elastin break down so to maintain the structure of health skin and therefore to form less amount of wrinkle so that's that's what we study for okay are there any questions please state your name and affiliation before asking your question yes right here she's bringing a microphone for you my name is cathode it's colonies from chemistry an industry magazine we hear a lot about products for the skin for collagen to stop wrinkles but I haven't heard much about last days are there other in last days inhibitors and how effective is your compound or is a series of compounds as an inhibitor compared with what's already available on the marketplace sure so this this protein is called elastase we see the inhibition effect

against those enzyme so we use a positive control called EGCG which is a common compounds you can find in green tea and that one is the positive control in well-accepted studies for this type of inhibition study and our compounds not all of them but some of our compounds isolated from red maple leaf extract metal IVA could actually showing better activity than the positive control egcg from green tea or a lot of other plants and in terms of the advocacy so we are now tested it's in the enzymatic based biochemical assays so it's no way it does involved with any cells or not animals or non-human is just start with the biochemical assays so in this and the Americas is may believe and its compound showing some good activity as compared to the positive control with allergies and inflammation or irritation of the skin what reasons do you have to believe that this will be low allergenicity or that we won't cause any other side effects or problems sure so I think this this maple leaf extract is unique first we know the chemistry very well those compounds are unique compounds and we also study data

seto toxicities of those compound and skin cells so up to 100 micrograms per ml or 100 micro molar those compounds are not toxic to the human keratinocytes each high cut cells so that's the in vivo cell based assays we're showing that those compound were not cytotoxic but further clinical studies needed to be conducted to confirm the safety of those compounds for great question so we actually studied a different part of this maple maple leaf maple tree so the leaves the bark the roots the all hunting these type of compounds but we have the idea to obtain sustainable resources for those compounds so we don't want to sacrifice the tree we don't want to cut off the roots take out the root rather than just pruning the tree and also collect the leaves which could naturally fall down in the in the in the fall so we can just collect the fall leaves on the ground or prune prune the tree together the leaves and which contain a lot of those bioactive compounds so that's one reason we trying to use a sustainable and the environmental friendly method to obtain those compounds follow-up question to that are you

finding more bio compound of these bio compounds in this in the summer or the fall leaves that you're harvesting right so there are difference if you harvest or if you you collect the leaves in the in the fall which is like a green leaves as we can showing here that's the green leaves and in the fall once the leaves turns a color to red so there's additional compounds for example and though science could be found in this type of leaves in the fall so the chemical characterization could be a little bit different however the majority of those chemical profiles for to extract a similar and additional additional compound could find in different extract for example anthocyanins in the fall extracts for leaf extracts you imagine this would be applied as a cream and if so would it have a more natural look and say Botox because I've heard that be very very obvious in some people right so our idea is to to create the products it's all based on natural resources botanical products can you remind me again your I was asking about the the effect of this have prepared the Botox in terms of whether it would look more natural on

the skin as opposed to Botox injections which appear to kind of give some people a kind of a look sure so exactly we're looking for a natural bait natural products based on our products so we don't know if the the the clinical outcome used as the Botox but we think that if it is natural it is less less toxic more safe so we expect better outcome in terms of their activity any other questions so elastic elastase is the enzyme that break down elastic the protein so we want to see in the biochemical assay we want to see if we can slow down the process of breaking down elastin so by inhibiting the activity of the elastase but this we haven't done it's in the in the human clinical study yet we don't know yet we are currently we are doing biophysical examination for the tie to study the type of inhibition if it is irreversible or like a non-competitive inhibitor but we're trying to to do more experiment to confirm the mechanism of the inhibition absolutely right so gal attending is commonly finding all kinds of plants but red maple I think it's a unique type of plant

first the demand of natural botanical based products is in high demand and you can get all kinds of different plant extract from all over the world anyplace in the world but red maple is unique because it's only grow in certain area most very civically the only grow in new eastern North America you cannot find this in any other countries or not even in west coast of the United States so we think it added it is a economic crop of this certain area and it is unique to this region so and also the compound find in this red maple leaf extract the gal attending the type of gal attorney are different from other Carol tannins from different different plants so that's the main major reason we choose the maple red maple because it's so local it's so it's the North America so our our research was conducted in collaboration with industry partners and the company we work with is ver do science in Noblesville Indiana so you University of Rhode Island and also Purdue science found it apart partially funded that they study so we intended to collaborate with industry partner and to commercialize this this extract to be our products hopefully with we still

have a lot of research work to do but hopefully it could be launched foot out for for commercialize commercially available products anything else I have a question do you think these maple leaf compounds could improve existing wrinkles as well as prevent new ones oh that's an interesting question we hope so we really wish we we really hope that would reverse the formation of wrinkle to reduce Winkle to make the skin look younger and we have studied some biases for example glycation of those compounds and the collocation is is a very is a chemical process that closely related to the skin aging wrinkle forming process and we're showing that those company had a good anti clock hit if effects but if it could reverse the the stage of wrinkle formation we need to study more to okay all right thank you the archived version of this session will soon be posted at bitly backslash ACS live underscore Boston 2018 please join us for our next press conference at 1:30 p.m. today on a new drug that could prevent mucositis a debilitating side effect of cancer treatment thank you thank you very much

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